GLP-1 Dose Titration Calendar
Generate a personalized week-by-week dose escalation schedule based on FDA prescribing guidelines. Select your medication and start date.
4 WEEKS PER STEP (FDA MINIMUM)
Initiation — letting your body adjust
Escalation
Escalation
Escalation
Maintenance (target dose)
Important notes for Wegovy
- 2.4 mg is the target maintenance dose. 1.7 mg is an acceptable alternative if 2.4 mg is not tolerated.
- If you can't tolerate a dose increase, stay at the current dose for an additional 4 weeks before trying again.
- Each dose step is a minimum of 4 weeks — your provider may extend to 6-8 weeks if needed.
What to expect during titration
GI side effects are common
Nausea affects ~44% of semaglutide and ~33% of tirzepatide users. It's usually worst in the first 1-2 weeks after each dose increase and improves.
The hardest dose jump
For semaglutide, the 0.5 mg to 1.0 mg step is often the toughest (it's a 100% increase). For tirzepatide, the 5 mg to 7.5 mg step tends to spike side effects.
Eat smaller meals
These medications slow gastric emptying. Eating pre-medication portion sizes is a top cause of nausea and bloating. Avoid high-fat, greasy foods after dose increases.
Slowing down is fine
If a dose increase causes persistent nausea beyond 2 weeks, drop back to the previous dose for a few weeks and retry. Many providers use 6-8 week intervals instead of 4.
Need a provider to manage your titration?
A good provider adjusts your schedule based on how you respond — not just a generic protocol. We'll match you with one.
Find My Provider