5-Amino-1MQ
Also known as: 5-Amino 1-Methylquinolinium
A small molecule (not technically a peptide) that blocks the NNMT enzyme involved in fat storage and energy metabolism. Animal studies show promising fat reduction without changes in diet, but there are zero published human clinical trials as of 2026.
How it works
5-Amino-1MQ inhibits an enzyme called NNMT (nicotinamide N-methyltransferase). When NNMT is overactive, it depletes NAD+, a molecule your cells need for energy. By blocking NNMT, 5-Amino-1MQ helps keep NAD+ levels up, which may activate SIRT1 (a longevity gene), improve insulin sensitivity, and shrink fat cells.
Common uses
- Fat loss and metabolic support
- NAD+ optimization
- Cellular energy and anti-aging research
- Body composition improvement
Side effects
- No published human safety data
- Mild GI discomfort reported anecdotally
- Slight stimulant-like effect (increased energy/alertness)
- Occasional mild headaches
- Long-term effects completely unknown
Key research
- 2018 study in Biochemical Pharmacology showed mice treated with NNMT inhibitors had reduced body weight, fat mass, and adipocyte size without changes in food intake
- Mouse studies showed 5.1% body weight reduction, 30%+ decrease in fat cell size, and 30% drop in total cholesterol in just 11 days
- No Phase 1, 2, or 3 human clinical trials have been published
Safety notes
- Zero published human clinical trial data. All evidence is from animal and cell studies
- Not FDA-approved and has not undergone FDA review
- Quality and purity vary widely between suppliers since it's unregulated
- Banned by WADA for athletic competition
- Should only be considered under medical supervision
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