Cerebrolysin
Also known as: FPF-1070
A mixture of brain-derived neurotrophic peptides extracted from pig brain tissue. It is used clinically in over 50 countries for stroke, dementia, and traumatic brain injury, but it is not FDA-approved in the United States.
How it works
Cerebrolysin contains a mix of low-molecular-weight neuropeptides and free amino acids from porcine brain tissue. These peptides mimic the action of natural neurotrophic factors, protecting nerve cells from damage, reducing brain inflammation, and supporting the growth of new neural connections. It works through multiple pathways including PI3K/AKT, GSK3-beta, and Sonic Hedgehog signaling.
Common uses
- Stroke recovery
- Dementia and Alzheimer's support
- Traumatic brain injury recovery
- General neuroprotection
Side effects
- Dizziness and headache
- Skin flushing and feeling hot
- Nausea
- Fatigue and insomnia
- Injection site reactions
- Very rare: anaphylactic reactions (only a handful of cases in published literature)
Key research
- CARS (Cerebrolysin and Recovery After Stroke) trial showed functional improvement after acute ischemic stroke
- Multiple clinical trials in 1,900+ TBI patients showed improvements in motor skills, cognition, and overall function
- Phase III trials for dementia and stroke completed in multiple European countries
- CLINCH trial (2025) evaluating Cerebrolysin in intracerebral hemorrhage with 88 patients
Safety notes
- Not approved by the FDA or available through US pharmacies
- Must be sourced internationally
- Given by intravenous or intramuscular injection only
- Requires medical supervision for administration
- Animal-derived product carries theoretical risk of allergic reactions
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