Dihexa
Also known as: PNB-0408, N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
An experimental peptide developed at Washington State University from the angiotensin IV system. It has generated interest because of animal research suggesting it is extremely potent at promoting new synapse formation, but it has no human clinical trials.
How it works
Dihexa activates the hepatocyte growth factor (HGF) and c-Met receptor system, which is involved in cell growth, repair, and the formation of new brain connections. Lab studies report it may be up to 10 million times more potent than BDNF at promoting new synapse formation, though this is only demonstrated in cell and animal studies.
Common uses
- Cognitive enhancement (experimental)
- Synaptogenesis research
- Alzheimer's disease research
- Neuroprotection research
Side effects
- No human safety data available
- Unknown long-term effects
- Potential for uncontrolled cell growth is a theoretical concern given its growth factor activity
- No established side effect profile in humans
Key research
- Original Washington State University research showed rescue of cognitive impairment in animal models
- 2021 study in APP/PS1 Alzheimer's mouse model showed cognitive improvement via PI3K/AKT pathway
- Fosgonimeton, a pro-drug of Dihexa, is in clinical trials for Alzheimer's and Parkinson's disease
Safety notes
- Zero human clinical trials have been completed for Dihexa itself
- Not FDA-approved for any indication
- No established dosing guidelines for humans
- The pro-drug fosgonimeton is the version being developed through proper clinical channels
- Extreme caution is warranted due to its potent growth factor activity
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