GHRP-6
Also known as: Growth Hormone Releasing Peptide-6, Growth Hormone Releasing Hexapeptide
One of the earliest synthetic growth hormone releasing peptides. Known for its strong GH-releasing effect and its very noticeable appetite stimulation. Less selective than newer options like ipamorelin, meaning it also raises cortisol and prolactin. Expected to return to legal compounding in 2026.
How it works
GHRP-6 is a synthetic hexapeptide that activates the ghrelin receptor in the pituitary gland, causing a strong pulse of growth hormone release. It also acts on hypothalamic neurons to powerfully stimulate appetite, more so than any other GHRP. It works best when stacked with a GHRH analog for maximum GH output.
Common uses
- Growth hormone stimulation
- Appetite stimulation (useful in underweight individuals)
- Recovery and tissue repair
- Body composition improvement
Side effects
- Intense hunger and increased appetite (most notable side effect)
- Water retention and bloating
- Elevated cortisol and ACTH levels
- Elevated prolactin
- Potential blood sugar dysregulation
- Injection site reactions
- Dizziness and headache
Key research
- Extensive research literature on GHRP-6 as a GH stimulation agent spanning decades
- Studies on cytoprotective effects show potential for organ protection beyond GH release
- Research demonstrates GHRP-6 stimulates both GH release and cortisol/prolactin, making it less selective than ipamorelin
Safety notes
- Not FDA-approved for any human therapeutic use
- Was placed on FDA Category 2 restricted list in 2023-2024
- Among the 14 peptides expected to return to Category 1 per February 2026 HHS announcement
- Raises cortisol more than ipamorelin, which can affect sleep, mood, and blood sugar
- No pharmaceutical-grade product exists. Quality varies between suppliers
- Requires metabolic and hormonal monitoring under medical supervision
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