Hexarelin
Also known as: Examorelin
The most potent growth hormone releasing peptide, producing the highest peak GH response of any GHRP. Also studied for cardiac protection and neuroprotection. However, it raises cortisol and prolactin more than other options and the body develops tolerance with continued use.
How it works
Hexarelin is a synthetic ghrelin analog that produces the strongest acute GH spike of any peptide in its class, boosting GH levels 100-140% above baseline. Beyond the ghrelin receptor, it also activates CD36 receptors in fat tissue and heart muscle, which may explain its unique effects on lipid metabolism and cardiac function that go beyond just raising GH.
Common uses
- Maximum growth hormone stimulation (research)
- Cardiac protection research
- Neuroprotection research
- Fat metabolism (via CD36 receptor activation)
Side effects
- Higher cortisol elevation than other GHRPs
- Higher prolactin elevation than other GHRPs
- Increased appetite
- Water retention
- Tingling and numbness in extremities
- Rapid tolerance development (GH response diminishes with continued use)
- Potential cardiac effects at sustained high doses
Key research
- Studies show hexarelin produces the highest peak GH response among available GHRPs
- Research found hexarelin improves left ventricular function in post-ischemic (after heart attack) animal models
- Studies demonstrate beneficial effects on lipid metabolism through CD36 receptor activation in non-obese insulin-resistant mice
- Neuroprotection research shows hexarelin decreases brain inflammation and increases hippocampal neurogenesis
Safety notes
- Not FDA-approved for any medical use
- Tolerance builds quickly. Most researchers use it in short-term protocols only
- Raises cortisol and prolactin significantly more than ipamorelin or GHRP-2
- Cardiac receptor activation means it should be used with particular caution in people with heart conditions
- Banned by WADA for athletic competition
- Limited to research settings. Not commonly prescribed clinically
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