Ipamorelin
Also known as: Ipamorelin Acetate
One of the most selective growth hormone secretagogues available. It triggers GH release from the pituitary without significantly raising cortisol or prolactin, which makes it cleaner than older GH peptides like GHRP-6. Previously restricted from compounding but expected to return to legal status in 2026.
How it works
Ipamorelin works by mimicking ghrelin, the hunger hormone, at the growth hormone secretagogue receptor (GHS-R) in the pituitary gland. But unlike ghrelin or GHRP-6, ipamorelin is highly selective. It triggers a clean GH pulse without the big cortisol or prolactin spikes you see with less selective GH peptides. This is why it's so popular as a standalone or paired with CJC-1295.
Common uses
- Growth hormone optimization
- Improved sleep quality
- Fat loss and body composition
- Recovery and tissue repair
- Anti-aging protocols
Side effects
- Mild increase in hunger
- Headache
- Water retention (mild)
- Tingling or numbness in extremities
- Injection site reactions
- Transient dizziness
Key research
- Studies demonstrate selective GH release with minimal effects on cortisol, prolactin, and ACTH
- Research shows ipamorelin produces dose-dependent GH release similar in pattern to natural GH pulsing
- Commonly studied in combination with CJC-1295 for synergistic GH elevation
Safety notes
- Not FDA-approved for any therapeutic use
- Was placed on FDA Category 2 restricted list in 2023-2024
- Among the 14 peptides expected to return to Category 1 per HHS announcement in February 2026, pending formal FDA publication
- Requires monitoring of IGF-1 levels
- Not appropriate for individuals with active cancer
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CJC-1295 / Ipamorelin
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