Kisspeptin-10
Also known as: Kisspeptin, Metastin 45-54, KISS1
The active fragment of the kisspeptin hormone, which is the master regulator of the reproductive hormone system. It triggers the release of GnRH, which then stimulates LH and FSH production. It is in Phase 2 clinical trials for reproductive and sexual health applications.
How it works
Kisspeptin-10 binds to the KISS1R receptor (also called GPR54) on GnRH neurons in the hypothalamus. This triggers the release of gonadotropin-releasing hormone (GnRH), which then stimulates the pituitary gland to release LH and FSH. These hormones control testosterone, estrogen, and other reproductive functions. A clinical trial in men with low sexual desire showed it also modulates sexual brain processing directly.
Common uses
- Reproductive hormone regulation (research)
- IVF oocyte maturation trigger (clinical trial)
- Hypoactive sexual desire disorder (clinical trial)
- Hypothalamic amenorrhea (clinical trial)
- Hypogonadism (clinical trial)
Side effects
- Hot flashes
- Injection site discomfort
- Headache
- Short half-life (about 4 minutes) requires frequent dosing
- Limited human safety data beyond clinical trials
Key research
- Randomized clinical trial showed kisspeptin modulates sexual brain processing and increases penile tumescence in men with HSDD (2023 PMC study)
- Completed Phase 2 trials in idiopathic hypogonadotropic hypogonadism, IVF triggering, and hypothalamic amenorrhea
- Human studies confirm potent stimulation of LH and FSH release in both men and women
Safety notes
- Not FDA-approved for any indication
- Very short half-life limits practical clinical use
- Active clinical trials continue to evaluate safety and dosing
- Should only be used under research or clinical trial supervision
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