KPV
Also known as: Lysine-Proline-Valine, Alpha-MSH Fragment
A tripeptide fragment of alpha-melanocyte stimulating hormone (alpha-MSH) with strong anti-inflammatory properties. Particularly studied for gut health and inflammatory bowel conditions. Available orally, topically, and by injection.
How it works
KPV is the smallest active fragment of alpha-MSH that keeps its anti-inflammatory power. It works by blocking NF-kB, a master switch for inflammation in your cells. It also reduces pro-inflammatory cytokines and has antimicrobial properties. When taken orally, it is absorbed through PepT1 transporters in the gut lining, making it effective for intestinal inflammation.
Common uses
- Gut inflammation and healing (IBD, colitis support)
- Inflammatory skin conditions
- General anti-inflammatory support
- Mucosal healing
Side effects
- Generally very well-tolerated with minimal reported side effects
- Mild injection site irritation (injectable form)
- Possible mild GI changes when taken orally
- Limited long-term safety data in humans
Key research
- Gastroenterology study showed oral KPV significantly reduced inflammation in mouse models of colitis (DSS and TNBS models)
- Research demonstrated KPV is absorbed through intestinal PepT1 transporters, explaining its gut-specific anti-inflammatory effects
- Alpha-MSH and KPV shown to inhibit NF-kB activation and reduce pro-inflammatory cytokine production in multiple studies
Safety notes
- Not FDA-approved for any medical use
- Was placed on FDA Category 2 restricted list, expected to return to Category 1 per 2026 reclassification
- Human clinical data is limited. Most evidence comes from animal and cell studies
- Should be used under medical supervision, especially for gut conditions
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