MK-677 / Ibutamoren
Also known as: MK-677, Ibutamoren, Ibutamoren Mesylate, Oratrope
A non-peptide, oral growth hormone secretagogue that mimics ghrelin to boost GH and IGF-1 levels. It's taken as a pill or liquid, not an injection. Not FDA-approved and has significant safety concerns including insulin resistance and a potential link to heart failure in elderly patients.
How it works
MK-677 is an oral compound that activates the ghrelin receptor (GHS-R1a), which triggers your pituitary gland to release growth hormone. It can increase GH levels by up to 97% and sustain elevated IGF-1 for extended periods. Because it's not a peptide, it survives digestion and works as an oral supplement, but it also significantly increases appetite.
Common uses
- Growth hormone and IGF-1 elevation
- Improved sleep quality
- Lean mass preservation
- Bone density support (research)
- Appetite stimulation in underweight populations
Side effects
- Increased appetite (very common and often significant)
- Water retention and bloating
- Insulin resistance and elevated blood sugar
- Muscle pain and joint pain
- Numbness and tingling in hands
- Increased blood pressure
- Risk of congestive heart failure in vulnerable populations
- Potential long-term cancer risk from chronically elevated IGF-1
Key research
- Studies show MK-677 increases GH secretion by up to 97% and raises IGF-1 into the normal young-adult range
- Research in elderly subjects showed increased lean body mass and improved sleep quality
- An older adult clinical trial was stopped due to increased risk of congestive heart failure
- Studies demonstrate significant insulin resistance with prolonged use
Safety notes
- FDA lists it as having 'significant safety risks' including potential for congestive heart failure
- Has not progressed past investigational status partly due to cardiovascular concerns
- Causes measurable insulin resistance. Not appropriate for people with diabetes or pre-diabetes
- Banned by WADA (prohibited at all times in sport)
- Widely sold online but not FDA-approved for any use
- Requires blood sugar and IGF-1 monitoring if used under medical supervision
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