Noopept
Also known as: Omberacetam, GVS-111, N-Phenylacetyl-L-prolylglycine ethyl ester
A synthetic nootropic dipeptide developed in Russia, related to the racetam family. It is used clinically in Russia for cognitive disorders but is not approved by the FDA. It is one of the more affordable and widely available nootropic peptides.
How it works
Noopept works by increasing BDNF and NGF (nerve growth factor) levels in the brain, which support the health and growth of nerve cells. It also modulates AMPA and NMDA glutamate receptors, which play a role in learning and memory. Unlike many peptides, Noopept can be taken orally because its small size allows it to cross the gut and blood-brain barrier.
Common uses
- Memory enhancement
- Cognitive function improvement
- Neuroprotection
- Focus and mental clarity
Side effects
- Sleep disturbances
- Irritability at higher doses
- Mild headache
- Increased blood pressure in some users
- Generally well-tolerated at standard doses of 10-30mg daily
Key research
- A 2013 systematic review of 19 clinical trials concluded Noopept effectively improves cognitive function with minimal adverse effects
- Open-label study showed 56-day treatment (10mg twice daily) improved mood and cognition in patients with mild cognitive disorders
- Cell studies show neuroprotective effects against amyloid-beta toxicity and tau hyperphosphorylation
Safety notes
- Not approved by the FDA for human use
- FDA has issued import alerts for omberacetam, treating it as an unapproved active pharmaceutical ingredient
- Sold as a supplement in some countries and as a prescription drug in Russia
- Considered part of the racetam family by the FDA
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